A Seroepidemiological study of Serogroup A meningococcal infection in the African meningitis belt Running title: Meningococcal antibodies in Africa
نویسندگان
چکیده
Olivier Manigart, Caroline Trotter, Helen Findlow, Abraham Assefa, Wude Mihret, Tesfaye Moti Demisse, Biruk Yeshitela, Isaac Osei, Abraham Hodgson, Stephen Laryea Quaye, Samba Sow, Mamadou Coulibaly, Kanny Diallo, Awa Traore, Jean-Marc Collard, Rahamatou Moustapha Boukary, Oumarou Djermakoye, 8 Ali Elhaji Mahamane, Jean-François Jusot, Cheikh Sokhna, Serge Alavo, Souleymane Doucoure, El Hadj Ba, Mariétou Dieng, Aldiouma Diallo, Doumagoum Moto Daugla, Babatunji Omotara, Daniel Chandramohan, Musa Hassan-King, Maria Nascimento, Arouna Woukeu, Ray Borrow, James M Stuart, Brian Greenwood*
منابع مشابه
Correction: A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt
The pattern of epidemic meningococcal disease in the African meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was established at five centres within the meningitis belt. Antibody concentrations were then measured...
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Context Although cases of Neisseria meningitidis serogroup A (NmA) in the African meningitis belt have declined dramatically following the extensive roll-out of MenAfriVac, a monovalent serogroup A conjugate vaccine, outbreaks due to other meningococcal serogroups have continued.1 More than 25 000 suspected cases of meningitis across the meningitis belt have been reported in each of the past 3 ...
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Peoples living in the 26 countries across the meningeal belt of Sub-Saharan Africa that stretches from Senegal to Ethiopia suffer from repeated epidemics of meningococcal disease. Literatures showed that epidemic meningococcal disease has been present in the stated region for more than 100 years. Though over 80% of cases of the African epidemics are associated with Neisseria meningitides serogr...
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A meningococcal serogroup A polysaccharide/tetanus toxoid conjugate vaccine (PsA-TT) (MenAfriVac(™) ) is being deployed in countries of the African meningitis belt. Experience with other polysaccharide/protein conjugate vaccines has shown that an important part of their success has been their ability to prevent the acquisition of pharyngeal carriage and hence to stop transmission and induce her...
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BACKGROUND To facilitate the interpretation of meningococcal meningitis epidemiology in the "African meningitis belt", we aimed at obtaining serogroup-specific pooled estimates of incidence, carriage and case-carrier ratios for meningococcal meningitis in the African meningitis belt and describe their variations across the endemic, hyperendemic and epidemic context. METHODS We conducted a sys...
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